SELECT PUBLICATIONS IN CANCER STEM CELL ENGINEERING
OVARIAN CANCER STEM CELLS AND MACROPHAGES RECIPROCALLY INTERACT THROUGH THE WNT PATHWAY TO PROMOTE PRO-TUMORAL AND MALIGNANT PHENOTYPES IN 3D ENGINEERED MICROENVIRONMENTS
Raghavan S, Mehta P, Xie Y, Lei YL, Mehta G
Using engineered spheroids, we show WNT activation during cancer stem cell-macrophages interaction constitutes a positive feedback loop. This interaction results in an aggressive, chemoresistant and invasive cancer phenotype.
SELECT PUBLICATIONS IN BIOMATERIALS AND STEM CELL ENGINEERING
THE INFLUENCE OF EXTRACELLULAR MATRIX COMPOSITION ON THE DIFFERENTIATION OF NEURONAL SUBTYPES IN TISSUE ENGINEERED INNERVATED INTESTINAL SMOOTH MUSCLE SHEETS.
August 2014, Biomaterials
Raghavan S, Bitar KN
We describe the formation of tissue engineered innervated sheets, where intestinal smooth muscle and enteric neural stem cells are brought into close association in extracellular matrix (ECM) based microenvironments. Our studies demonstrated that neuronal subtype was modulated by varying ECM composition. This observation could be utilized to derive enriched populations of specific enteric neurons in vitro prior to transplantation.
SELECT PUBLICATIONS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE
PERIANAL IMPLANTATION OF BIOENGINEERED HUMAN INTERNAL ANAL SPHINCTER CONSTRUCTS INTRINSICALLY INNERVATED WITH HUMAN NEURAL PROGENITOR CELLS
Raghavan S, Miyasaka EA, Gilmont RR, Somara S, Teitelbaum DH, Bitar KN
We descibe a regenerative medicine based therapy for fecal incontinence that would directly address the dysfunction of the Internal Anal Sphincter (IAS) muscle. Human IAS tissue constructs were bioengineered from isolated human IAS circular smooth muscle cells and human enteric neuronal progenitor cells. Our results indicate that bioengineered innervated IAS constructs can be used to augment IAS function in an animal model.