Here are some recent publications coming from members of our lab!
Here, PhD candidate Abbie Clevenger studied the effect of peristalsis on the enrichment of colorectal cancer stem cells and acquisition of malignant invasion. We have found that peristalsis significantly increases the emergence of cancer stem cells.
Here we have created a peristalsis simulating machine that we used to study colorectal cancer with!
This research identifies distinct cell cycle dysregulation modes (ATM mutation, CHK2 dysregulation, ATR/TP53 co-mutation) in breast cancer, impacting subtype, metastatic potential, and treatment responsiveness. Considering cell cycle dysregulation in diagnostic classification is emphasized as crucial based on these findings.
This study explores Gulf War Illness (GWI) caused by chemical exposure during the Gulf War, focusing on gastrointestinal motility. Findings in male C57BL/6 mice exposed to pyridostigmine bromide (PB) show severe enteric neuro-inflammation, reduced colonic motility, elevated pro-inflammatory markers, decreased enteric neurons, and smooth muscle hypertrophy, underscoring the significance of understanding GWI mechanisms for improving therapeutic interventions and veterans' well-being.
This study investigates the roles of macrophages in ovarian cancer tumor microenvironment and their impact on disease progression. It identifies the correlation of increased expression of specific surface proteins (SIRPα, CD47, CD163, and CD68) with advanced OvCa stages. The development of a novel nanomedicine-based immunotherapy targeting SIRPα enhances platinum resistance reduction, suggesting potential for combined treatment strategies in high-stage OvCa patients.
This patent describes solid films and articles with distinct regions patterned using a deposited low molecular weight organic compound, potentially comprising pharmaceutical actives and new chemical entities. These regions may contain the organic compound at ≥ about 99% mass and exhibit either crystalline or amorphous characteristics, and the deposition process involves organic vapor jet printing in an inert gas stream, resulting in high surface area films that display enhanced solubility and bioavailability for the organic compound.
This study presents a novel device based on liquid crystal elastomers (LCEs) that can change shape in response to temperature increase induced by transcutaneous IR light. The LCE-based device demonstrated the ability to support continence and adjust sling tension in a scar tissue phantom model, an in vitro urinary tract model, and acute implantation in female multiparous New Zealand white rabbits, offering potential for dynamic and non-invasive treatment of stress urinary incontinence (SUI) in women.
The textbook chapter discusses the impact of the tumor microenvironment (TME) in 3D space on tumor progression, metastasis, and chemoresistance through interactions between malignant and non-malignant cells, as well as the extracellular matrix. The TME's composition, comprising diverse non-malignant cell types, varies among tumor types and individuals, presenting a significant challenge to comprehend for effective cancer research and personalized treatments.
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